Ion Pair-Based Potentiometric Sensors for Selective and Sensitive Determination of Lomefloxacin

Abstract

This study reports the fabrication of two novel electrochemical sensors for the quantitative determination of the drug Lomefloxacin (LOM), employing LOM–silicotungstic acid (STA) and LOM–molybdophosphoric acid (MPA) ion pairs as electroactive materials. The sensors were systematically characterized in terms of gradient, linear concentration range, detection limit, response time, pH tolerance and shelf life. The applicability of the sensors was demonstrated by successfully determining LOM in pharmaceutical tablet formulations as well as in real samples such as urine using the standard addition method. The proposed sensors exhibited long operational lifetimes, high stability, sensitivity, precision, accuracy and selectivity. Moreover, they offer a cost-effective, simple and rapid analytical approach for routine LOM determination.