Enantioselective Catalytic Three-Component Synthesis of Optically Active Propargyl Amino Ethers

Abstract

Catalytic enantioselective three-component aminomethylation of benzaldehyde as well as its methoxy-substituted derivatives and propargyl ethers with aniline in the presence of a chiral catalyst – pseudoephedrine – yielded previously unknown optically active propargyl amino ethers with high yields and a high degree of enantioselectivity. This reaction can also be used to form both C-C and C-N bonds.